Intrathecal Methotrexate and Acute Neurotoxicity: A Painful Experience
نویسندگان
چکیده
Intrathecal treatment with methotrexate, an essential chemotherapeutic for both prophylaxis and treatment of central nervous system involvement of leukemia, may be associated with local neurotoxicity and/or systemic toxicity. Signs of acute neurotoxicity include confusion, disorientation, seizures, aphasia, ataxia, dysarthria, paresis and even paralysis. Presented here is a case of a 58 year old patient with acute lymphoblastic leukemia who developed acute neurotoxicity after her 13th dose of intrathecal methotrexate. Available treatment options are also discussed.
منابع مشابه
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Dear Editor, Methotrexate (MTX) is a frequently used chemotherapeutic agent in the treatment of childhood acute lymphoblastic leukaemia (ALL) and lymphoma. Besides oral and intravenous MTX, intrathecal MTX is an essential component of chemotherapy for ALL and is effective in preventing recurrences of central nervous system (CNS) leukaemia. Acute, subacute and chronic neurotoxicity have been obs...
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